( click the link to review the publication ), PubMed: 27070098 NLM Direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM. Epub 2007 Oct 24. VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. Mol Cancer Ther.

Semin Cancer Biol. * When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. ( click the link to review the publication ), PubMed: 29666304 Utilizing these SMIs in such a way may prove to decrease the patient drug load by diminishing the required chemo-/radiotherapy dose. Venetoclax is … : ( click the link to review the publication ), PubMed: 29058102 ( click the link to review the publication ), PubMed: 26375587 ( click the link to review the publication ), PubMed: 30257201 Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol. Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. ( click the link to review the publication ), PubMed: 28187446 ( click the link to review the publication ), PubMed: 31687977 ( click the link to review the publication ), PubMed: 31004033 ( click the link to review the publication ), PubMed: 26467384 A549 cells were treated with Ibr-7, ABT-199 or a combination for 24 h before western blotting assay.

( click the link to review the publication ), PubMed: 27056884 ( click the link to review the publication ), PubMed: 28280274 ( click the link to review the publication ), PubMed: 31927215

A-1331852 is a potent and selectiveBCL-XL inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. AMG-176 is a selective MCL1 inhibitor with Ki values of 0.06 nM, 0.7 μM and 0.95 μM for MCL-1, Bcl-xL and Bcl-2 respectively. ( click the link to review the publication ), PubMed: 32369455 ( click the link to review the publication ), PubMed: 30647404

( click the link to review the publication ), PubMed: 29403054 BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.

( click the link to review the publication ), PubMed: 20842105 ( click the link to review the publication ), PubMed: 30692684 ( click the link to review the publication ), PubMed: 26497853 Dose-limiting toxicity to healthy tissues is among the major hurdles in anticancer treatment along with intrinsic or acquired multi-drug resistance. ( click the link to review the publication ), PubMed: 26246472 ( click the link to review the publication ), PubMed: 26156752 Cancer J. Expert Opin Emerg Drugs. ( click the link to review the publication ), PubMed: 28988970