Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase. Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures. Dr. Young completed a residency at University of California-San Francisco. Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects. Apoprotein B-100 production is decreased in subjects heterozygous for truncations of apoprotein B. Asymptomatic homozygous hypobetalipoproteinemia associated with apolipoprotein B45.2. ANGPTL4 inactivates lipoprotein lipase by catalyzing the irreversible unfolding of LPL's hydrolase domain. Acad. Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression. These five symptoms should be evaluated by a doctor. Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients. Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice. Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid. GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding. GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells. They sound similar, but each serves different populations—though there can be some overlap. Sometimes, a cancer diagnosis can make people feel robbed of a voice in their treatment decisions.

Lipoprotein lipase is active as a monomer. Office environment, cleanliness, comfort, etc. He overlooked that added stroke and that disqualified him from the tournament and a playoff—the harshest penal... Talking to Your Doctor About Rheumatoid Arthritis, Gynecology, Vascular & Interventional Radiology, Cardiology (Cardiovascular Disease), Internal Medicine, 650 Charles E Young Dr S, Los Angeles, CA 90095, 200 Medical Plz # 365, Los Angeles, CA 90095, FDA Approves Two New Drugs to Treat High Cholesterol, Likelihood of recommending Dr. Young to family and friends, Tell us about your experience with Dr. Young. Sci. A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation.

Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease. Palmoplantar keratoderma in Slurp1/Slurp2 double-knockout mice. Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1. Lowering plasma cholesterol by raising LDL receptors--revisited. He has been in practice for more than 20 years.

Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding. Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria. 2020 May 3, He, C., Jiang, H., Song, W., Riezman, H., Tontonoz, P., Weston, T. A., Guagliardo, P., Kim, P. H., Jung, R., Heizer, P., Fong, L. G., Young, S. G.> ;Proceedings of the National Academy of Sciences of the United States of America. Multicenter Evaluation of the QIAstat-Dx Respiratory Panel for Detection of Viruses and Bacteria in Nasopharyngeal Swab Specimens.

Washington University School of Medicine in St. Louis, The American Society for Clinical Investigation, 1991, Belling, J. N., Heidenreich, L. K., Tian, Z., Mendoza, A. M., Chiou, T., Gong, Y., Chen, N. Y., Young, T. D., Wattanatorn, N., Park, J. H., Scarabelli, L., Chiang, N.,...> ;Proceedings of the National Academy of Sciences of the United States of America. Acad.

Dr. Stephen G. Young is a cardiologist in Los Angeles, California and is affiliated with one hospital.

Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis. Concentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina. Clinical Performance of the Novel GenMark Dx ePlex Blood Culture ID Gram-Positive Panel. Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain. The fatty acids from LPL-mediated processing of triglyceride-rich lipoproteins are taken up rapidly by cardiomyocytes. 2020 May 2, Kristensen, K. K., Leth-Espensen, K. Z., Young, S. G., Ploug, M.> ;Journal of lipid research. Disclaimer and a note about your health ». Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores. Deficiency of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Leads to Progressive Loss of Photoreceptor Function. GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism. Sci. An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death. Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells.

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